High Frequency or Prolonged use of Mouthwash Increased Risk of Head and Neck Cancer

Do you use mouthwash?  You might want to read this article!   Read more below and thank you  for visiting Advanced Endodontics, Lakewood, Ohio!

A number of case-control studies have suggested a link between mouthwash use and head and neck cancer.

The aim of this analysis was to provide more definitive evidence on the presence or absence of an association between mouthwash use and head and neck cancer using individual-level data on a very large number of cases and controls


All studies in the International Head and Neck Cancer Epidemiology Consortium (INHANCE) with data on mouthwashes were used. Pooled data from 12 case-controlled studies including 8,981 cases (83.0% confirmed squamous cell carcinomas) and 10,090 controls was combined. In most studies, controls were frequency-matched to cases on the basis of age and sex. Cases were categorized by tumor site (oral cavity, N = 2790; oropharynx, N = 2632; hypopharynx, N = 577; larynx, N = 1793).

Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education.

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